|
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We therefore investigated the anti-tumor properties of a gold(I) <i>N</i>-heterocyclic carbene (NHC) complex-termed MC3-in human colorectal cancer (CRC) cell lines encompassing three different p53 variations: HCT116 wild-type (WT), HCT116 p53<sup>-/-</sup>, and HT-29 (mutant; R273H).
|
31231607 |
2019 |
|
rs11540652
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We show that the most common mutp53 allele R248Q (p53<sup>Q</sup>) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displacing the phosphatase SHP2.
|
30107178 |
2018 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched multiple electronic databases to identify studies investigating the association between the Arg72Pro polymorphism and colorectal cancer.
|
20615891 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched multiple electronic databases to identify studies investigating the association between the Arg72Pro polymorphism and colorectal cancer.
|
20615891 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We did not identify an association between TP53 rs1042522 and colorectal cancer.
|
20615891 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC.
|
23183747 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC.
|
23183747 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC.
|
23183747 |
2013 |
|
rs746504075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |
|
rs1427471466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |